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Unveiling the epigenomic mechanisms of acquired platinum‐resistance in high‐grade serous ovarian cancer

8 Mar 2023

Abstract excerpt

Resistance to platinum-based chemotherapy is the major cause of death from high-grade serous ovarian cancer (HGSOC). We hypothesise that detection of specific DNA methylation changes may predict platinum resistance in HGSOC. Using a publicly available "discovery" dataset we examined epigenomic and transcriptomic alterations between primary platinum-sensitive (n = 32) and recurrent acquired drug resistant HGSOC (n...

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PMID: 36883413
DOI: 10.1002/ijc.34496

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