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DNA Methylation and Transcriptomic Features are Preserved Throughout Disease Recurrence and Chemoresistance in High Grade Serous Ovarian Cancers

2022-01-06

Abstract excerpt

<title>Abstract</title> <p>Background Little is known about the role of global DNA methylation in recurrence and chemoresistance of high grade serous ovarian cancer (HGSOC). We performed whole genome bisulfite sequencing and transcriptome sequencing in 62 primary and recurrent tumors from 28 patients with stage III/IV HGSOC, of which 11 patients carried germline, pathogenic <italic>BRCA1</italic> and/or <italic>...

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Literature Corpus work
a65dd418-c97c-51f7-92d5-2169f901e355
DOI
10.21203/rs.3.rs-1214611/v1
Open publication

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DNA Methylation and Transcriptomic Features are Preserved Throughout Disease Recurrence and Chemoresistance in High Grade Serous Ovarian CancersDOI 10.21203/rs.3.rs-1214611/v1
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