Article

Blood Based Biomarkers of DNA Methylation Associated with Platinum Resistance in High Grade Serous Ovarian Cancer

2026-04-24

Abstract excerpt

<h4>Background</h4> High grade serous ovarian cancer (HGSC) is initially a responsive tumor to platinum (Pt)-based therapy. Pt resistance in HGSC is associated with epigenetic modifications and hypomethylating agents (HMAs) have been studied as carboplatin resensitizing agents. As DNA methylation is detectable in cancer cells and in blood, here we aimed to develop a blood-based methylation signature associated wi...

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Literature Corpus work: 742d7b85-97ff-57f8-9505-30fcc2247c24
DOI: 10.64898/2026.04.23.720362

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