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Article

TRIM23 mediates cGAS-induced autophagy in anti-HSV defense

13 May 2025

Abstract excerpt

The cGAS-STING pathway, well-known to elicit interferon (IFN) responses, is also a key inducer of autophagy upon virus infection or other stimuli. Whereas the mediators for cGAS-induced IFN responses are well characterized, much less is known about how cGAS elicits autophagy. Here, we report that TRIM23, a unique TRIM protein harboring both ubiquitin E3 ligase and GTPase activity, is crucial for...

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PMID: 40360474
DOI: 10.1038/s41467-025-59338-5

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