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Article

Does ethnicity impact CYP2D6 genotype-phenotype relationships?

Clinical and translational science - 1 Jun 2023

Frederiksen Trine, Areberg Johan, Schmidt Ellen, Stage Tore Bjerregaard, Brøsen Kim

Abstract excerpt

Polymorphism of the CYP2D6 gene leads to substantial interindividual variability in CYP2D6 enzyme activity. Despite improvements in prediction of CYP2D6 activity based on genotype information, large interindividual variability within CYP2D6 genotypes remains and ethnicity could be a contributing factor. The aim of this study was to investigate interethnic differences in CYP2D6 activity using clinical datasets of...

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PMID: 36869607
DOI: 10.1111/cts.13506
PMCID: PMC10264946

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