Article
Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: clinical implications.
The oncologist - 1 Feb 2006
Bernard Stephen, Neville Kathleen A, Nguyen Anne T, Flockhart David A
Abstract excerpt
DNA polymorphisms have been identified in the genes encoding a number of the cytochrome P450 (CYP) enzymes, leading to wide interindividual variation in drug clearance. CYP2D6 metabolizes a significant number of clinically used medications, and genetic variants of the CYP2D6 isozyme that result in varying levels of metabolic activity are of clinical importance in some settings. The exact nature of the clinical...
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