Article
Validation of a genotyping technique for a surrogate marker of HLA-B∗58:01 for allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in the Japanese population.
Drug metabolism and pharmacokinetics - 1 Apr 2023
Tsukagoshi Eri, Nakamura Ryosuke, Tanaka Yoichi, Maekawa Keiko, Hiratsuka Masahiro, Asada Hideo, Saito Yoshiro
Abstract excerpt
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare but severe cutaneous adverse drug reactions. Certain human leukocyte antigen (HLA) types have been associated with SJS/TEN onset, e.g., HLA-B∗58:01 with allopurinol-induced SJS/TEN, but HLA typing is time-consuming and expensive; thus, it is not commonly used in clinical situations. In the previous work, we demonstrated that the...
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