Article
Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing.
Scientific reports - 7 Nov 2019
Nakatani Ken, Ueta Mayumi, Khor Seik-Soon, Hitomi Yuki, Okudaira Yuko, Masuya Anri, Wada Yuki, Sotozono Chie, Kinoshita Shigeru, Inoko Hidetoshi, Tokunaga Katsushi
Abstract excerpt
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening acute inflammatory vesiculobullous reactions of the skin and mucous membranes. These severe cutaneous drug reactions are known to be caused by inciting drugs and infectious agents. Previously, we have reported the association of HLA-A*02:06 and HLA-B*44:03 with cold medicine (CM)-related SJS/TEN with severe ocular...
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