Article
Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B*58:01: a partially predictive but useful biomarker for allopurinol-related Stevens-Johnson syndrome/toxic epidermal necrolysis in Japanese.
Drug metabolism and pharmacokinetics - 1 Jan 2012
Maekawa Keiko, Nishikawa Jun, Kaniwa Nahoko, Sugiyama Emiko, Koizumi Tomoko, Kurose Kouichi, Tohkin Masahiro, Saito Yoshiro
Abstract excerpt
Allopurinol-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is strongly associated with HLA-B*58:01 in various populations including Japanese. We demonstrated that several single nucleotide polymorphisms (SNPs) around the HLA region on chromosome 6 were strongly linked wit...
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