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Article

Diagnostic utility of HLA-B*5801 screening in severe allopurinol hypersensitivity syndrome: an updated systematic review and meta-analysis.

International journal of rheumatic diseases - 1 Sept 2017

Yu Kuang-Hui, Yu Cheng-Yen, Fang Yao-Fan

Abstract excerpt

BACKGROUND: Despite many studies suggesting an association between human leukocyte antigen (HLA)-B*5801 and allopurinol-induced toxic epidermal necrolysis (TEN) and Stevens-Johnsons syndrome (SJS), the evidence of association in different populations and the degree of association remain uncertain. METHODS: The primary analysis was based on population-control studies. Data were pooled by means of a random-effects...

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PMID: 28857441
DOI: 10.1111/1756-185X.13143

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Diagnostic utility of HLA-B*5801 screening in severe allopurinol hypersensitivity syndrome: an updated systematic review and meta-analysis.PMID 28857441Read ↗

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