NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease.

doi:10.1007/s00535-015-1142-4

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease.

Journal of gastroenterology - 1 Jan 2016

Asada Ayumi, Nishida Atsushi, Shioya Makoto, Imaeda Hirotsugu, Inatomi Osamu, Bamba Shigeki, Kito Katsuyuki, Sugimoto Mitsushige, Andoh Akira

Abstract excerpt

BACKGROUND: NUDT15 R139C (rs116855232) is a recently identified genetic factor responsible for thiopurine-induced leukocytopenia and hair loss. In this study, we investigated the association of NUDT15 R139C with 6-thioguanine nucleotide (6-TGN) levels and thiopurine-induced leukocytopenia in Japanese patients with inflammatory bowel disease (IBD). METHODS: Two hundred and sixty-four subjects (103 healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alopecia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotides

Share to Inflammatory Bowel Diseases

Share to Leukocyte Count

Share to Leukopenia

Share to Mercaptopurine

Share to Pyrophosphatases

Share to Thionucleotides

Source

Open in PubMed

Identifiers

PMID: 26590936
DOI: 10.1007/s00535-015-1142-4

Genes

NUDT15

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease.PMID 26590936Read ↗

NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD.Semantic proximity Read ↗

NUDT15,FTO, andRUNX1genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseasesSemantic proximity Read ↗

NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.Semantic proximity Read ↗

Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines.Semantic proximity Read ↗

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia.Semantic proximity Read ↗

Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel diseaseSemantic proximity Read ↗

Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.Semantic proximity Read ↗

NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review.Semantic proximity Read ↗

Prevalence of NUDT15 Genetic Variants and Incidence of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia.Semantic proximity Read ↗

Pharmacogenetic Risk Factors for Thiopurine-Induced Leukopenia in Patients with Inflammatory Bowel Disease.Semantic proximity Read ↗

NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine-induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.