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Article

Multiple phenotype association tests using summary statistics in genome-wide association studies.

Biometrics - 1 Mar 2018

Liu Zhonghua, Lin Xihong

Abstract excerpt

We study in this article jointly testing the associations of a genetic variant with correlated multiple phenotypes using the summary statistics of individual phenotype analysis from Genome-Wide Association Studies (GWASs). We estimated the between-phenotype correlation matrix using the summary statistics of individual phenotype GWAS analyses, and developed genetic association tests for multiple phenotypes by...

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PMID: 28653391
DOI: 10.1111/biom.12735
PMCID: PMC5743780

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