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Article

A novel method to test associations between a weighted combination of phenotypes and genetic variants.

PloS one - 1 Jan 2018

Zhu Huanhuan, Zhang Shuanglin, Sha Qiuying

Abstract excerpt

Many complex diseases like diabetes, hypertension, metabolic syndrome, et cetera, are measured by multiple correlated phenotypes. However, most genome-wide association studies (GWAS) focus on one phenotype of interest or study multiple phenotypes separately for identifying genetic variants associated with complex diseases. Analyzing one phenotype or the related phenotypes separately may lose power due to ignoring...

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PMID: 29329304
DOI: 10.1371/journal.pone.0190788
PMCID: PMC5766098

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