Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN

1 Mar 2023

Abstract excerpt

Abstract We report herein that TSPAN32 is a key node factor for Philadelphia (Ph+) leukemia pathogenesis. We found that TSPAN32 expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib treatment inhibited the proliferation of Ph+ cell lines. Tspan32 overexpression significantly prevented BCR-ABL induced leukemia progression in a murine model and impaired leukemia stem cell (LSC)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Chronic Myeloid Leukemia Treatments
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36854750
DOI: 10.1038/s41392-022-01290-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTENPMID 36854750Read ↗

ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cellsSemantic proximity Read ↗

The Role of PTEN in Myeloid MalignanciesSemantic proximity Read ↗

Super enhancer related gene ANP32B promotes the proliferation of acute myeloid leukemia by enhancing MYC through histone acetylationSemantic proximity Read ↗

Molecular Regulation and Oncogenic Functions of TSPAN8Semantic proximity Read ↗

Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.Semantic proximity Read ↗

PTEN is a tumor suppressor in CML stem cells and BCR-ABL–induced leukemias in miceSemantic proximity Read ↗

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.Semantic proximity Read ↗

Tspan protein family: focusing on the occurrence, progression, and treatment of cancerSemantic proximity Read ↗

Anthelmintic niclosamide suppresses transcription of BCR-ABL fusion oncogene via disabling Sp1 and induces apoptosis in imatinib-resistant CML cells harboring T315I mutant.Semantic proximity Read ↗

SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic miceSemantic proximity Read ↗

Small Peptide Targeting ANP32A as a Novel Strategy For Acute Myeloid Leukemia TherapySemantic proximity Read ↗

RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.