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Article

ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells

6 Aug 2021

Abstract excerpt

Proper regulation of p53 signaling is critical for the maintenance of hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs). The hematopoietic cell-specific mechanisms regulating p53 activity remain largely unknown. Here, we demonstrate that conditional deletion of acidic leucine-rich nuclear phosphoprotein 32B (ANP32B) in hematopoietic cells impairs repopulation capacity and postinjury regeneration of...

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PMID: 34359074
DOI: 10.1182/blood.2020010400

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