Article

RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia

2023-05-25

Abstract excerpt

Philadelphia chromosome-positive (Ph + ) leukemia is a fatal hematological malignancy. Although standard treatments with tyrosine kinase inhibitors (TKI) have achieved remarkable success in prolonging patient survival, intolerance, relapse and TKI resistance remain serious issues for patients with Ph + leukemia. Here, we report a new leukemogenic process in which RAPSYN and BCR-ABL co-occur in Ph + leukemia, an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2ae27188-127b-5d5c-89b8-a89e697d13d7
DOI: 10.1101/2023.05.24.542110

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive LeukemiaDOI 10.1101/2023.05.24.542110Read

Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABLSemantic proximity Read

Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemiaSemantic proximity Read

Kill Two Birds with One Stone: A Multifunctional Dual‐Targeting Protein Drug to Overcome Imatinib Resistance in Philadelphia Chromosome‐Positive LeukemiaSemantic proximity Read

Emerging roles of pseudokinases.Semantic proximity Read

Regulatory Molecules and Corresponding Processes of BCR-ABL Protein DegradationSemantic proximity Read

NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia.Semantic proximity Read

A KLF4-DYRK2–mediated pathway regulating self-renewal in CML stem cellsSemantic proximity Read

Differential signaling networks of Bcr–Abl p210 and p190 kinases in leukemia cells defined by functional proteomicsSemantic proximity Read

Regulation of proto-Dbl by intracellular membrane targeting and protein stability.Semantic proximity Read

SHP2 is required for BCR-ABL1-induced hematologic neoplasiaSemantic proximity Read

SRC: A Century of Science Brought to the ClinicSemantic proximity Read

TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTENSemantic proximity Read