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Article

Disruption of polyhomeotic polymerization decreases nucleosome occupancy and alters genome accessibility.

Life science alliance - 1 May 2023

Amin Adfar, Kadam Sangram, Mieczkowski Jakub, Ahmed Ikhlak, Bhat Younus A, Shah Fouziya, Tolstorukov Michael Y, Kingston Robert E, Padinhateeri Ranjith, Wani Ajazul H

Abstract excerpt

Chromatin attains its three-dimensional (3D) conformation by establishing contacts between different noncontiguous regions. Sterile Alpha Motif (SAM)-mediated polymerization of the polyhomeotic (PH) protein regulates subnuclear clustering of Polycomb Repressive Complex 1 (PRC1) and chromatin topology. The mutations that perturb the ability of the PH to polymerize, disrupt long-range chromatin contacts, alter Hox...

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Identifiers

PMID: 36849253
DOI: 10.26508/lsa.202201768
PMCID: PMC9973501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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