Article
Whole Exome Sequence Analysis for Inborn Errors of IL-12/IFN-γ Axis in Patient with Recurrent Typhoid Fever.
BioMed research international - 1 Jan 2023
Hassan Faaiz Ul, Aljeldah Mohammed M, Fozia Fozia, Hussain Mubbashir, Khan Taj Ali, Siraj Sami, Ahmad Ijaz, Qasim Muhammad, Khan Imran, Giesy John P, Aboul-Soud Mourad A M
Abstract excerpt
Background: The IL-12/IFN-γ axis pathways play a vital role in the control of intracellular pathogens such as Salmonella typhi. Objective: The study is aimed at using whole exome sequencing (WES) to screen out genetic defects in IL-12/IFN-γ axis in patients with recurrent typhoid fever. Methods: WES using next-generation sequencing was performed on a single patient diagnosed with recurrent typhoid fever....
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