Article

Human variation impacting <i>MCOLN2</i> restricts <i>Salmonella</i> Typhi replication by magnesium deprivation

2022-05-08

Abstract excerpt

Human genetic diversity can reveal critical factors in host-pathogen interactions. This is especially useful for human-restricted pathogens like Salmonella enterica serovar Typhi ( S . Typhi), the cause of Typhoid fever. One key dynamic during infection is competition for nutrients: host cells attempt to restrict intracellular replication by depriving bacteria of key nutrients or delivering toxic metabolites in...

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Literature Corpus work: e77c8547-a3f3-5145-8f20-846aa00764a7
DOI: 10.1101/2022.05.08.491078

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