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Article

Whole-Exome Sequencing for the Identification of Genetic Factors Implicated in Severe Bacterial Infections: A Systematic Review.

The Journal of infectious diseases - 17 Mar 2026

Gélin Morgane, Launay Élise, Vince Nicolas

Abstract excerpt

BACKGROUND: Severe bacterial infections (SBIs) represent a major health issue worldwide. Many studies have explored patients' genetic predispositions to SBI, but most of them chose a candidate-gene design. Only few adopted a whole-exome sequencing (WES) approach. We aimed at reporting nontargeted WES studies describing genetic variants associated with SBI susceptibility in previously healthy patients without a...

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Identifiers

PMID: 41499460
DOI: 10.1093/infdis/jiag006
PMCID: PMC13017026

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