Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inguinal Fat Compensates Whole Body Metabolic Functionality in Partially Lipodystrophic Mice with Reduced PPARγ Expression.

International journal of molecular sciences - 15 Feb 2023

Chang Cherng-Shyang, Yu Shang-Shiuan, Ho Li-Chun, Chao Shu-Hsin, Chou Ting-Yu, Shao Ai-Ning, Kao Ling-Zhen, Chang Chia-Yu, Chen Yu-Hsin, Wu Ming-Shan, Tsai Pei-Jane, Maeda Nobuyo, Tsai Yau-Sheng

Abstract excerpt

Peroxisome proliferator-activated receptor γ (PPARγ) gene mutations in humans and mice lead to whole-body insulin resistance and partial lipodystrophy. It is unclear whether preserved fat depots in partial lipodystrophy are beneficial for whole-body metabolic homeostasis. We analyzed the insulin response and expression of metabolic genes in the preserved fat depots of PpargC/- mice, a familial partial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insulin
Share to Insulin Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipodystrophy

Share to Lipodystrophy, Familial Partial

Share to Mutation

Share to PPAR gamma

Source

Open in PubMed Open full text

Identifiers

PMID: 36835312
DOI: 10.3390/ijms24043904
PMCID: PMC9966317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inguinal Fat Compensates Whole Body Metabolic Functionality in Partially Lipodystrophic Mice with Reduced PPARγ Expression.PMID 36835312Read ↗

Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity.Semantic proximity Read ↗

Mouse models of PPAR-γ deficiency: dissecting PPAR-γ's role in metabolic homoeostasisSemantic proximity Read ↗

Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in MiceSemantic proximity Read ↗

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.Semantic proximity Read ↗

Mouse models of inherited lipodystrophy.Semantic proximity Read ↗

Obesity-associated improvements in metabolic profile through expansion of adipose tissue.Semantic proximity Read ↗

Familial partial lipodystrophy resulting from loss-of-function PPARγ pathogenic variants: phenotypic, clinical, and genetic features.Semantic proximity Read ↗

PPARdelta regulates glucose metabolism and insulin sensitivity.Semantic proximity Read ↗

PPARgamma: a critical determinant of body fat distribution in humans and mice.Semantic proximity Read ↗

Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice.Semantic proximity Read ↗

A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome.Semantic proximity Read ↗

Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.