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Article

Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells

16 Jan 2023

Abstract excerpt

Recombinant adeno-associated virus (rAAV) is a clinically proven viral vector for delivery of therapeutic genes to treat rare diseases. Improving rAAV manufacturing productivity and vector quality is necessary to meet clinical and commercial demand. These goals will require an improved understanding of the cellular response to rAAV production, which is poorly defined. We interrogated the kinetic transcriptional...

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PMID: 36819978
DOI: 10.1016/j.omtm.2023.01.002

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