Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans

22 Feb 2023

Abstract excerpt

BACKGROUND: The clinical course and outcome of many diseases differ between women and men, with women experiencing a higher prevalence and more severe pathogenesis of autoimmune diseases. The precise mechanisms underlying these sex differences still remain to be fully understood. IRF5 is a master transcription factor that regulates TLR/MyD88-mediated responses to pathogen-associated molecular patterns (PAMPS) in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Systemic Lupus Erythematosus Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36814288
DOI: 10.1186/s13293-023-00495-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humansPMID 36814288Read ↗

IRF5-mediated signaling and implications for SLE.Semantic proximity Read ↗

Regulating IRFs in IFN Driven DiseaseSemantic proximity Read ↗

Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosusSemantic proximity Read ↗

IRF5-mediated immune responses and its implications in immunological disordersSemantic proximity Read ↗

Gender-dependent Expression of Murine Irf5 Gene: Implications for Sex Bias in AutoimmunitySemantic proximity Read ↗

Monoallelic IRF5 deficiency in B cells prevents murine lupusSemantic proximity Read ↗

Sex-related immunity: could Toll-like receptors be the answer in acute inflammatory response?Semantic proximity Read ↗

Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases.Semantic proximity Read ↗

Role for interferon regulatory factors in autoimmunity.Semantic proximity Read ↗

Gender differences of B cell signature related to estrogen-induced IFI44L/BAFF in systemic lupus erythematosusSemantic proximity Read ↗

Four Promoters of IRF5 Respond Distinctly to Stimuli and are Affected by Autoimmune-Risk PolymorphismsSemantic proximity Read ↗

Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.