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Article

Gender-dependent Expression of Murine Irf5 Gene: Implications for Sex Bias in Autoimmunity

27 Aug 2010

Abstract excerpt

Molecular mechanisms that contribute to sex bias in the development of systemic lupus erythematosus (SLE), an autoimmune disease, remain unknown. We found that the expression levels of interferon regulatory factor 5 (IRF5), a lupus susceptibility factor, depend on gender of mice. We found that steady-state levels of the Irf5 mRNA were relatively higher in splenic cells from certain autoimmune-prone mice (for...

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PMID: 20802013
DOI: 10.1093/jmcb/mjq023

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