Article
Associations between variants in levodopa metabolic pathway genes and levodopa-induced dyskinesia in Parkinson's disease.
Neuroscience letters - 28 Mar 2023
Yan Jia-Hui, Ge Yi-Lun, Wang Pu-Zhi, Li Wen, Jin Hong, Zhang Jin-Ru, Chen Jing, Wang Fen, Li Dan, Mao Cheng-Jie, Li Kai, Liu Chun-Feng
Abstract excerpt
INTRODUCTION: Levodopa-induced dyskinesia (LID) is a common motor complication in Parkinson's disease (PD). Several genes in the levodopa metabolic pathway, such as COMT, DRDx and MAO-B, were reported associated with LID. However, there has been no systematic analyses between common variants in levodopa metabolic pathway genes and LID in a large sample of the Chinese population. METHODS: Through the whole exome...
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