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Article

A systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson's disease.

BMC medical genomics - 19 Sept 2017

Guin Debleena, Mishra Manish Kumar, Talwar Puneet, Rawat Chitra, Kushwaha Suman S, Kukreti Shrikant, Kukreti Ritushree

Abstract excerpt

BACKGROUND: PD is a progressive neurodegenerative disorder commonly treated by levodopa. The findings from genetic studies on adverse effects (ADRs) and levodopa efficacy are mostly inconclusive. Here, we aim to identify predictive genetic biomarkers for levodopa response (LR) and determine common molecular link with disease susceptibility. A systematic review for LR was conducted for ADR, and drug efficacy,...

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Source

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Identifiers

PMID: 28927418
DOI: 10.1186/s12920-017-0291-0
PMCID: PMC5606117

Genes

COMT
DRD2
FYN
HOMER1
MTHFR
SNCA
SRC
UBC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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