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Article

Exome-wide association study of levodopa-induced dyskinesia in Parkinson's disease.

Scientific reports - 1 Oct 2021

König Eva, Nicoletti Alessandra, Pattaro Cristian, Annesi Grazia, Melotti Roberto, Gialluisi Alessandro, Schwienbacher Christine, Picard Anne, Blankenburg Hagen, Pichler Irene, Modugno Nicola, Ciullo Marina, Esposito Teresa, Domingues Francisco S, Hicks Andrew A, Zappia Mario, Pramstaller Peter P

Abstract excerpt

Levodopa is the standard long-term dopamine replacement therapy to treat Parkinson's disease (PD) symptoms. With time, levodopa may induce debilitating dyskinesias (LID), the treatment of which represents a large clinically unmet need. However, time-to-LID onset varies between patients, reflecting a possible genetic component. We performed an hypothesis-free whole-exome sequencing (WES)-based screening of...

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Identifiers

PMID: 34599261
DOI: 10.1038/s41598-021-99393-8
PMCID: PMC8486836

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