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Article

ALK Gene Mutation and ALK Protein Expression in Advanced Neuroblastoma and the Potential Value in Risk Stratification in Fine-Needle Aspiration Biopsy Samples.

American journal of clinical pathology - 4 Apr 2023

Bhardwaj Neha, Rohilla Manish, Gautam Upasana, Trehan Amita, Bansal Deepak, Kakkar Nandita, Srinivasan Radhika

Abstract excerpt

OBJECTIVES: The protein ALK is targeted for therapy in neuroblastoma, and ALK mutation confers a poor prognosis. We evaluated ALK in a cohort of patients with advanced neuroblastoma diagnosed by fine-needle aspiration biopsy (FNAB). METHODS: Fifty-four cases of neuroblastoma were evaluated for ALK protein expression by immunocytochemistry and ALK gene mutation by next-generation sequencing. MYCN amplification by...

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Share to Anaplastic Lymphoma Kinase
Share to Biopsy, Fine-Needle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to N-Myc Proto-Oncogene Protein

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Source

Identifiers

PMID: 36812383
DOI: 10.1093/ajcp/aqac172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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