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PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells

22 Feb 2023

Abstract excerpt

Myelodysplastic syndrome (MDS) is a clonal malignancy arising in hematopoietic stem cells (HSCs). The mechanisms of MDS initiation in HSCs are still poorly understood. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway is frequently activated in acute myeloid leukemia, but in MDS, PI3K/AKT is often down-regulated. To determine whether PI3K down-regulation can perturb HSC function, we generated a triple knockout...

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PMID: 36812307
DOI: 10.1126/sciadv.ade8222

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