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Article

Autophagy Sustains Hematopoiesis Through Targeting Notch

15 Jul 2015

Abstract excerpt

Autophagy is required for hematopoietic stem cell multilineage differentiation, but the underlying mechanism is unknown. Using a conditional mouse model and human leukemia cells, we uncovered a mechanistic link between autophagy and hematopoietic stem cell differentiation. Loss of autophagy in mouse hematopoietic stem cells diminished the bone marrow generation of functional blood cells, in particular...

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PMID: 26178296
DOI: 10.1089/scd.2015.0176

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