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Article

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

21 Feb 2011

Abstract excerpt

The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance of adult mouse hematopoietic stem cells (HSCs) remains unknown. Although normal HSCs sustain life-long hematopoiesis, malignant transformation of HSCs leads to leukemia. Therefore, mechanisms protecting HSCs from cellular damage are essential to prevent hematopoietic malignancies. In this study, we crippled...

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PMID: 21339326
DOI: 10.1084/jem.20101145

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