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Obesity impacts the expression of Alzheimer's disease–related genes: The Framingham Heart Study

22 Feb 2023

Abstract excerpt

INTRODUCTION: We investigated associations of obesity with the expression of Alzheimer's disease (AD)-related genes in a large community-based cohort. METHODS: The sample consisted of 5619 participants from the Framingham Heart Study. Obesity metrics included body mass index (BMI) and waist-to-hip ratio (WHR). Gene expression was measured for a set of 74 AD-related genes, derived by integrating genome-wide...

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PMID: 36811231
DOI: 10.1002/alz.12954

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