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Article

Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2014

Hinney Anke, Albayrak Ozgür, Antel Jochen, Volckmar Anna-Lena, Sims Rebecca, Chapman Jade, Harold Denise, Gerrish Amy, Heid Iris M, Winkler Thomas W, Scherag André, Wiltfang Jens, Williams Julie, Hebebrand Johannes

Abstract excerpt

Deviations from normal body weight are observed prior to and after the onset of Alzheimer's disease (AD). Midlife obesity confers increased AD risk in later life, whereas late-life obesity is associated with decreased AD risk. The role of underweight and weight loss for AD risk is controversial. Based on the hypothesis of shared genetic variants for both obesity and AD, we analyzed the variants identified for AD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24788522
DOI: 10.1002/ajmg.b.32234

Genes

CELF1
APOE
DNAJC27
FERMT2
IQCK
PICALM
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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