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Article

Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats.

Scientific reports - 21 Feb 2023

Tanaka Yasutake, Kawano Michio, Nakashima Sawako, Yamaguchi Chisato, Asahina Makoto, Sakamoto Mai, Shirouchi Bungo, Tashiro Kousuke, Imaizumi Katsumi, Sato Masao

Abstract excerpt

Suppressor of mek1 (Dictyostelium) homolog 2 (Smek2), was identified as one of the responsible genes for diet-induced hypercholesterolemia (DIHC) of exogenously hypercholesterolemic (ExHC) rats. A deletion mutation in Smek2 leads to DIHC via impaired glycolysis in the livers of ExHC rats. The intracellular role of Smek2 remains obscure. We used microarrays to investigate Smek2 functions with ExHC and...

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Identifiers

PMID: 36810603
DOI: 10.1038/s41598-022-26115-z
PMCID: PMC9944932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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