Article

MFSD7c functions as a transporter of choline at the blood-brain barrier

2023-10-03

Abstract excerpt

Mutations of MFSD7c (also known as Flvcr2 ), which is an orphan transporter, are linked to Fowler syndrome 1, 2 . Here, we use Mfsd7c knockout mice and cell-based assays to reveal that MFSD7c is a choline transporter at the blood-brain barrier (BBB). We performed comprehensive metabolomics and detected differential changes of metabolites in the brains and livers of Mfsd7c knockout ( Mfsd7c −/− ) embryos. Part...

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Literature Corpus work: 90be7afd-1603-5532-8500-84a534a03b34
DOI: 10.1101/2023.10.03.560597

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