Article
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
PloS one - 21 Oct 2009
Noll Christophe, Planque Chris, Ripoll Clémentine, Guedj Fayçal, Diez Anna, Ducros Véronique, Belin Nicole, Duchon Arnaud, Paul Jean-Louis, Badel Anne, de Freminville Bénédicte, Grattau Yann, Bléhaut Henri, Herault Yann, Janel Nathalie, Delabar Jean-Maurice
Abstract excerpt
BACKGROUND: Hyperhomocysteinemia, characterized by increased plasma homocysteine level, is associated with an increased risk of atherosclerosis. On the contrary, patients with Down syndrome appear to be protected from the development of atherosclerosis. We previously found a deleterious effect of hyperhomocysteinemia on expression of DYRK1A, a Down-syndrome-associated kinase. As increased expression of DYRK1A and...
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