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Article

Impact of DNA methyltransferases on bacterial fitness and genome stability in Escherichia coli.

Journal of global antimicrobial resistance - 1 Jan 2026

Kim Jee Hong, Kim Hyunkeun, Ko Kwan Soo

Abstract excerpt

OBJECTIVE: DNA methylation, catalysed by DNA methyltransferases (MTases), plays a crucial role in bacterial physiology. In this study, we investigated the effects of the DNA MTases, DNA adenine methyltransferase (Dam) and DNA cytosine methyltransferase (Dcm), on bacterial fitness and mutation rates in Escherichia coli. METHODS: We constructed an E. coli K-12 MG1655 strain lacking both the dam and dcm genes...

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Identifiers

PMID: 41412349
DOI: 10.1016/j.jgar.2025.12.009

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