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GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors

15 Feb 2023

Abstract excerpt

BACKGROUND: Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital hypothyroidism (CH) in both humans and mice due to decreased expression of several thyroid hormone (TH) biosynthetic genes in thyroid follicular cells. Whether and to what extent, GLIS3 regulates thyroid gene transcription in coordination with other thyroid transcriptional factors (TFs), such as PAX8, NKX2.1 and FOXE1,...

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PMID: 36793061
DOI: 10.1186/s13578-023-00979-8

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