Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular and clinical genetics of the transcription factor GLIS3 in Chinese congenital hypothyroidism.

Molecular and cellular endocrinology - 15 May 2021

Zhang Rui-Jia, Zhang Jun-Xiu, Du Wen-Hua, Sun Feng, Fang Ya, Zhang Cao-Xu, Wang Zheng, Wu Feng-Yao, Han Bing, Liu Wei, Zhao Shuang-Xia, Liang Jun, Song Huai-Dong

Abstract excerpt

The transcription factor GLIS3 is an important factor in hormone biosynthesis and thyroid development, and mutations in GLIS3 are relatively rare. Deletions of more than one of the 11 exons of GLIS3 occur in most patients with various extrathyroidal abnormalities and congenital hypothyroidism (CH), and only 18 missense variants of GLIS3 related to thyroid disease have been reported. The aim of this study was to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Congenital Hypothyroidism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Protein Transport

Share to Repressor Proteins

Share to Thyroid Hormones

Share to Trans-Activators

Source

Identifiers

PMID: 33667596
DOI: 10.1016/j.mce.2021.111223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular and clinical genetics of the transcription factor GLIS3 in Chinese congenital hypothyroidism.PMID 33667596Read ↗

Two novel mutations in Gli-similar 3 in patients with congenital hypothyroidism and thyroid dysgenesisSemantic proximity Read ↗

Mutation screening of the GLIS3 gene in a cohort of 592 Chinese patients with congenital hypothyroidism.Semantic proximity Read ↗

Case report: Neonatal diabetes mellitus with congenital hypothyroidism as a result of biallelic heterozygous mutations in GLIS3 gene.Semantic proximity Read ↗

GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factorsSemantic proximity Read ↗

The role of GLIS3 in thyroid disease as part of a multisystem disorder.Semantic proximity Read ↗

Novel GLIS3 mutations demonstrate an extended multisystem phenotype.Semantic proximity Read ↗

Expanding the Clinical Spectrum Associated With GLIS3 Mutations.Semantic proximity Read ↗

Case Report: Neonatal Diabetes Mellitus Caused by a Novel GLIS3 Mutation in Twins.Semantic proximity Read ↗

GLIS1–3 transcription factors: critical roles in the regulation of multiple physiological processes and diseasesSemantic proximity Read ↗

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.Semantic proximity Read ↗

Mutation screening of eight genes and comparison of the clinical data in a Chinese cohort with congenital hypothyroidismSemantic proximity Read ↗

Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.