Article
Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.
PLoS genetics - 1 Feb 2021
Aprea Isabella, Raidt Johanna, Höben Inga Marlena, Loges Niki Tomas, Nöthe-Menchen Tabea, Pennekamp Petra, Olbrich Heike, Kaiser Thomas, Biebach Luisa, Tüttelmann Frank, Horvath Judit, Schubert Maria, Krallmann Claudia, Kliesch Sabine, Omran Heymut
Abstract excerpt
Axonemal protein complexes, such as outer (ODA) and inner (IDA) dynein arms, are responsible for the generation and regulation of flagellar and ciliary beating. Studies in various ciliated model organisms have shown that axonemal dynein arms are first assembled in the cell cytoplasm and then delivered into axonemes during ciliogenesis. In humans, mutations in genes encoding for factors involved in this process...
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