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Article

GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse

31 Oct 2019

Abstract excerpt

BACKGROUND: The sperm protein IZUMO1 (Izumo sperm-egg fusion 1) and its recently identified binding partner on the oolemma, IZUMO1R, are among the first ligand-receptor pairs shown to be essential for gamete recognition and adhesion. However, the IZUMO1-IZUMO1R interaction does not appear to be directly responsible for promoting the fusion of the gamete membranes, suggesting that this critical phase of the...

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PMID: 31672133
DOI: 10.1186/s12915-019-0701-1

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