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Article

Polygenic risk scores for genetic counseling in psychiatry: Lessons learned from other fields of medicine.

Neuroscience and biobehavioral reviews - 1 Feb 2021

Eeltink E, van der Horst M Z, Zinkstok J R, Aalfs C M, Luykx J J

Abstract excerpt

Polygenic risk scores (PRS) may aid in the identification of individuals at-risk for psychiatric disorders, treatment optimization, and increase in prognostic accuracy. PRS may also add significant value to genetic counseling. Thus far, integration of PRSs in genetic counseling sessions remains problematic because of uncertainties in risk prediction and other concerns. Here, we review the current utility of PRSs...

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Identifiers

PMID: 33301779
DOI: 10.1016/j.neubiorev.2020.11.021

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