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Article

Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats.

Behavioural brain research - 12 Apr 2023

Mäkinen Elina, Wikgren Jan, Pekkala Satu, Koch Lauren G, Britton Steven L, Nokia Miriam S, Lensu Sanna

Abstract excerpt

Good aerobic fitness associates positively with cognitive performance and brain health and conversely, low aerobic fitness predisposes to neurodegenerative diseases. To study how genotype together with exercise, started at older age, affects brain and behavior, we utilized rats that differ in inherited aerobic fitness. Rats bred for Low Capacity for Running (LCR) are shown to display less synaptic plasticity and...

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Identifiers

PMID: 36774999
DOI: 10.1016/j.bbr.2023.114331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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