Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic analysis of a rat model of aerobic capacity and metabolic fitness.

PloS one - 1 Jan 2013

Ren Yu-Yu, Overmyer Katherine A, Qi Nathan R, Treutelaar Mary K, Heckenkamp Lori, Kalahar Molly, Koch Lauren G, Britton Steven L, Burant Charles F, Li Jun Z

Abstract excerpt

Aerobic capacity is a strong predictor of all-cause mortality and can influence many complex traits. To explore the biological basis underlying this connection, we developed via artificial selection two rat lines that diverge for intrinsic (i.e. inborn) aerobic capacity and differ in risk for complex disease traits. Here we conduct the first in-depth pedigree and molecular genetic analysis of these lines, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breeding
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exercise Tolerance

Share to Genetic Fitness

Share to Linkage Disequilibrium

Share to Physical Conditioning, Animal

Share to Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 24147032
DOI: 10.1371/journal.pone.0077588
PMCID: PMC3795692

Genes

F2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of a rat model of aerobic capacity and metabolic fitness.PMID 24147032Read ↗

Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk.Semantic proximity Read ↗

Intrinsic aerobic capacity sets a divide for aging and longevity.Semantic proximity Read ↗

Shared and distinct adaptations to early-life exercise training based on inborn fitnessSemantic proximity Read ↗

Aerobic capacity-dependent differences in cardiac gene expressionSemantic proximity Read ↗

Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype.Semantic proximity Read ↗

Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform.Semantic proximity Read ↗

Animal genetic models for complex traits of physical capacity.Semantic proximity Read ↗

Power and precision: Evaluation and recommendations of quantitative trait analysis methods for RNA expression levels in the Hybrid Rat Diversity PanelSemantic proximity Read ↗

Genetic architecture of voluntary exercise in an advanced intercross line of mice.Semantic proximity Read ↗

The HERITAGE family study. Aims, design, and measurement protocol.Semantic proximity Read ↗

Phenotypic effects of the "mini-muscle" allele in a large HR x C57BL/6J mouse backcross.Semantic proximity Read ↗

Intrinsic (Genetic) Aerobic Fitness Impacts Susceptibility for Metabolic Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.