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Integrating transcriptome-wide association study and mRNA expression profile identified candidate genes related to hand osteoarthritis.

Arthritis research & therapy - 10 Mar 2021

Xu Jiawen, Zeng Yi, Si Haibo, Liu Yuan, Li Mingyang, Zeng Junfeng, Shen Bin

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is a common skeletal system disease that has been partially attributed to genetic factors. The hand is frequently affected, which seriously affects the patient's quality of life. However, the pathogenetic mechanism of hand osteoarthritis (hand OA) is still elusive. METHODS: A genome-wide association study (GWAS) summary of hand OA was obtained from the UK Biobank dataset, which...

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PMID: 33691763
DOI: 10.1186/s13075-021-02458-2
PMCID: PMC7948369

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