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Article

Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila.

Genetics - 1 Jun 2007

Liu Wensheng, Gnanasambandam Radhakrishnan, Benjamin Jeffery, Kaur Gunisha, Getman Patricia B, Siegel Alan J, Shortridge Randall D, Singh Satpal

Abstract excerpt

Mitochondrial dysfunction is involved in many neurodegenerative disorders in humans. Here we report mutations in a gene (designated levy) that codes for subunit VIa of cytochrome c oxidase (COX). The mutations were identified by the phenotype of temperature-induced paralysis and showed the additional phenotypes of decreased COX activity, age-dependent bang-induced paralysis, progressive neurodegeneration, and...

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Identifiers

PMID: 17435251
DOI: 10.1534/genetics.107.071688
PMCID: PMC1894620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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