Article
Genetic predisposition to smoking in relation to the risk of frailty in ageing.
Scientific reports - 10 Feb 2023
Liu Wei, Yang Hong, Lv Linshuoshuo, Song Jie, Jiang Yuqing, Sun Xiaohui, Ye Ding, Mao Yingying
Abstract excerpt
Frailty causes emerging global health burden due to its high prevalence and mortality. In this study, we used Mendelian randomization (MR) approach to examine the potential causal relationship between smoking and frailty in ageing. Using inverse-variance weighted (IVW) method, genetically predicted smoking initiation was associated with an increased risk of frailty in ageing (odd ratio (OR) 1.23, 95% confidence...
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