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The causal association between plasma caffeine and frailty: A two-sample mendelian randomization study.

Archives of gerontology and geriatrics - 1 Mar 2025

Mi Yuze, Lin Shaokai, Chen Ke, Shu Zhendi

Abstract excerpt

BACKGROUND: Frailty is one of the most common and challenging consequences of aging, which negatively affects older adults, their families, and society. Caffeine has been shown to be associated with a reduced risk of frailty by observational studies, yet its causal relationship with frailty remains to be tested using more robust methods. AIMS: This study aimed to explore the causal association between plasma...

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Aged
Caffeine
Frail Elderly
Frailty
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 39616874
DOI: 10.1016/j.archger.2024.105706

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