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Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study.

Clinical nutrition (Edinburgh, Scotland) - 1 Jul 2025

Zhong Wen-Fang, Wang Xiao-Meng, Song Wei-Qi, Chen Huan, Xie Jia-Hao, Yan Hao, Wang Jun-Jie, Lv Yue-Bin, Li Zhi-Hao, Shi Xiao-Ming, Mao Chen

Abstract excerpt

BACKGROUND: The association between change in lifestyle in late-life and frailty mediated by genetic risk is yet to be elucidated. This study aimed to investigate the associations of change in lifestyle in late-life and genetic risk with frailty among older adults. METHODS: 6945 participants aged 65 or older were included from the Chinese Longitudinal Healthy Longevity Survey. Three-year lifestyle changes were...

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PMID: 40367593
DOI: 10.1016/j.clnu.2025.04.033

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