Article
Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder.
Nature communications - 24 Oct 2017
Andrews Shan V, Ellis Shannon E, Bakulski Kelly M, Sheppard Brooke, Croen Lisa A, Hertz-Picciotto Irva, Newschaffer Craig J, Feinberg Andrew P, Arking Dan E, Ladd-Acosta Christine, Fallin M Daniele
Abstract excerpt
Integration of emerging epigenetic information with autism spectrum disorder (ASD) genetic results may elucidate functional insights not possible via either type of information in isolation. Here we use the genotype and DNA methylation (DNAm) data from cord blood and peripheral blood to identify SNPs associated with DNA methylation (meQTL lists). Additionally, we use publicly available fetal brain and lung meQTL...
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